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M9470033.TXT
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1994-07-02
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Document 0033
DOCN M9470033
TI [Antimalarial 10 H-indolo(3,2-b)quinolin-11-yl-amines. 1.
Phenol-Mannich-bases of the amodiaquine and cycloquine type.
DT 9409
AU Gorlitzer K; Stockmann R; Walter RD; Institut fur Pharmazeutische
Chemie, Technischen Universitat; Braunschweig.
SO Pharmazie. 1994 Apr;49(4):231-5. Unique Identifier : AIDSLINE
MED/94255521
AB The 11-chloro-quinoline derivatives 3 react with 4-aminophenol and the
mono- and bis-phenol-Mannich-bases 6 to yield the
10H-indolo[3,2-b]quinoline-11-yl-amines 4 and 7. The amodiaquine
analogue 7a as the best of all compounds shows a comparable activity
with choroquine and inhibits a multiresistant Plasmodium falciparum
strain at the same concentration. Compound 7e from the cycloquine-type
was selected for an in vivo antitumor screening programme.
DE Aminoquinolines/*CHEMICAL SYNTHESIS/PHARMACOLOGY Animal
Antimalarials/*CHEMICAL SYNTHESIS/PHARMACOLOGY Antiviral
Agents/PHARMACOLOGY Drug Resistance Drug Screening Assays, Antitumor
English Abstract Human HIV-1/DRUG EFFECTS In Vitro Indoles/*CHEMICAL
SYNTHESIS/PHARMACOLOGY Plasmodium falciparum/DRUG EFFECTS JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).